AURANOFIN INHIBITS THE ENZYME ACTIVITY OF PASTEURELLA MULTOCIDA TOXIN PMT IN HUMAN CELLS AND PROTECTS CELLS FROM INTOXICATION

Auranofin Inhibits the Enzyme Activity of Pasteurella multocida Toxin PMT in Human Cells and Protects Cells from Intoxication

The AB-type protein toxin from Pasteurella multocida (PMT) contains a functionally important disulfide bond within its catalytic domain, which must be cleaved in the host cell cytosol to render the catalytic domain of PMT into its active conformation.Here, we found that the reductive potential of the cytosol of target cells, and more specifically,

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